STARD3 (START domain containing 3)

STARD 13 ( star - related lipid transfer ( START ) domain containing 13 )

DLC2 was identified due to striking sequence homology to DLC1. It localizes to a small region of 13q12.3, which is a locus frequently deleted in hepatocellular carcinoma (HCC) as well as in other cancers. Physical mapping of DLC2 in human genome revealed that it is in close proximity to the BRCA2 locus and flanked by microsatellite markers D13S171 and D13S267. The human DLC2 gene spans a region...

LYPD3 (LY6/PLAUR domain containing 3)

Note The gene for human C4.4A is located on chromosome 19q13, only 180 kb apart from the urokinase-type plasminogen activator receptor (uPAR) gene, in a cluster encompassing all presently known glycosylphosphatidylinositol (GPI)-anchored, multidomain proteins of the Ly6/uPAR/alpha-neurotoxin (LU) domain family. Description 4870 bp; 5 exons (Figure 1). Transcription Transcription of the C4.4A ge...

BRWD 3 ( bromodomain and WD repeat domain containing 3 )

Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein.

We have identified an Arabidopsis mutant that displays enhanced disease resistance (edr2) to the biotrophic powdery mildew pathogen Erysiphe cichoracearum. Inhibition of fungal growth on edr2 mutant leaves occurred at a late stage of the infection process and coincided with formation of necrotic lesions approximately 5 days after inoculation. Double-mutant analysis revealed that edr2-mediated r...

SET and MYND domain containing protein 3 in cancer.

Lysine methylation plays a vital role in histone modification. Deregulations of lysine methyltransferases and demethylases have been frequently observed in human cancers. The SET and MYND domain containing protein 3 (SMYD3) is a novel histone lysine methyltransferase and it functions by regulating chromatin during the development of myocardial and skeletal muscle. It has been recently unveiled ...